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Vicia Villosa Lectin (VVL, VVA) |
This lectin is a family of tetrameric glycoproteins consisting
of combinations of A and B subunits similar in structure to
PHA and GSL I. The dominant isolectins in our preparations
appear to be B subunit-rich. VVL recognizes preferentially α- or
β-linked terminal N-acetylgalactosamine, especially a single
α-N-acetylgalactosamine residue linked to serine or
threonine in a polypeptide (the Tn antigen). Evidence suggests
that this lectin also may require specific amino acid sequences
at the receptor site of glycosylation. The disaccharide galactosyl
(α-1,3) N-acetylgalactosamine is also a potent inhibitor of this lectin.
Inhibiting/Eluting Sugar: 200 mM N-acetylgalactosamine
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