GSL I is a family of glycoproteins with molecular weights of
approximately 114 kDa. There are two types of subunits,
termed “A” and “B”, with slightly different molecular weights.
These subunits combine to form tetrameric structures,
resulting in five isolectins. The “A”-rich lectin preferentially
agglutinates blood group A erythrocytes and thus appears to
be specific for α-N-acetylgalactosamine residues, while the
“B”-rich lectin preferentially agglutinates blood group B cells
and is specific for α-galactose residues. Our GSL I is a mixture
of the five isolectins. GSL I has been reported to bind several
glycoproteins including laminin.
GSL I-B4 isolectin contains only the B subunits. It is a useful
marker for endothelial cells from nonprimates such as mouse,
rat, rabbit, and goat as well as a marker for non-peptidergic
unmyelinated primary afferent neurons.
Inhibiting Sugar: 500 mM galactose or 100 mM raffinose
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References for GSL, IB4
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