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Immuno-oncology research often hinges on the ability to characterize complex biological systems—the tumor microenvironment, effector T cells, immune checkpoints, to name a few. Probing these systems requires tools that reliably capture the spatial biology, perform in preclinical models, and maintain the integrity of precious patient samples. Five recent publications spanning pediatric neuro-oncology, tumor immune evasion, … Continued
Obesity is a disease with broad causes and effects. The study, diagnosis, and treatment of obesity have implications from the population level down to the individual (but interconnected) biological pathways in each person. The study of systems like adipokine signaling, appetite regulation, lipid metabolism, chronic inflammation, and insulin sensitivity help researchers gain better understanding of … Continued
When researchers design a protein expression study, the standard toolkit of IHC, IF, flow cytometry, and other techniques can tell them a great deal about where a protein is and how much of it is present. What those methods typically leave out is glycosylation: the post-translational modification that in many cases determines how a protein … Continued
